Founded in 1876, Calvin Theological Seminary (CTS) is the oldest denominational ministry and the only seminary affiliated with the Christian Reformed Church which is comprised of approximately 300,000 members in over 1,000 congregations across the United States and Canada. The Seminary is located in Grand Rapids, Michigan and is closely tied to Calvin College, though each school has its own Board of Trustees. Though CTS is affiliated with the CRCNA, nearly half of the students are from other denominations.

At present, Calvin Theological Seminary offers four Masters programs (Master of Divinity, Master of Arts, Master of Theological Studies and Master of Theology), one Doctorate program (Doctor of Philosophy) and a variety of ecclesiastical programs. The Seminary's foundation is Reformed theology and is thoroughly committed to the Bible as God's Word and to the confessional standards of the Belgic Confession, the Heidelberg Catechism, and the Canons of Dort as a faithful interpretation of the Word.

In 2011, Rev. Julius Ted Medenblik became the president of CTS.